mouse LRP6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Lrp6.
shAAV-263817
AAV-m-LRP6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Lrp6 (low density lipoprotein receptor-related protein 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>; skax26
Description (Vector)
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Gene ID
16974
Gene Name (Vector)
low density lipoprotein receptor-related protein 6
Gene Symbol
Lrp6
ORF Size (aa)
4842
ORF Size (bp)
4842 bp
RefSeq ID
NM_008514
RefSeq Synonyms
NM_008514, BC060704,
Species
mouse
UniGene ID
Mm.321990
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.