mouse LINGO1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Lingo1.
shAAV-263468
AAV-m-LINGO1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Lingo1 (leucine rich repeat and Ig domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4930471K13Rik; AV148400; LERN1; LINGO-1; Lrrn6a; UNQ201
Description (Vector)
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Gene ID
235402
Gene Name (Vector)
leucine rich repeat and Ig domain containing 1
Gene Symbol
Lingo1
ORF Size (aa)
1845
ORF Size (bp)
1845 bp
RefSeq ID
NM_181074
RefSeq Synonyms
NM_181074, NM_001311076, BC065696, BC052384,
Species
mouse
UniGene ID
Mm.246605
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.