mouse ZNRF1 shRNA silencing AAV

Name
AAV-m-ZNRF1-shRNA

Cat No
shAAV-263353

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Znrf1.

shAAV-263353

AAV-m-ZNRF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Znrf1 (zinc and ring finger 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B830022L21Rik; nin283; Rnf42; Zrfp1

Description (Vector)

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Gene ID

170737

Gene Name (Vector)

zinc and ring finger 1

Gene Symbol

Znrf1

ORF Size (aa)

684

ORF Size (bp)

684 bp

RefSeq ID

NM_133206

RefSeq Synonyms

NM_133206, NM_001168623, NM_001168622, NM_001168621, BC086770, BC006765,

Species

mouse

UniGene ID

Mm.271578

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.