mouse KLHL21 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Klhl21.
shAAV-262907
AAV-m-KLHL21-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Klhl21 (kelch-like 21). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1810045K06Rik; D330008A20; mKIAA0469
Description (Vector)
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Gene ID
242785
Gene Name (Vector)
kelch-like 21
Gene Symbol
Klhl21
ORF Size (aa)
1794
ORF Size (bp)
1794 bp
RefSeq ID
NM_001033352
RefSeq Synonyms
NM_001033352, BC141159, BC141158,
Species
mouse
UniGene ID
Mm.22306
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.