mouse KEAP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Keap1.
shAAV-262778
AAV-m-KEAP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Keap1 (kelch-like ECH-associated protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
INRF2; mKIAA0132
Description (Vector)
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Gene ID
50868
Gene Name (Vector)
kelch-like ECH-associated protein 1
Gene Symbol
Keap1
ORF Size (aa)
1875
ORF Size (bp)
1875 bp
RefSeq ID
NM_016679
RefSeq Synonyms
NM_016679, NM_001110307, NM_001110306, NM_001110305, BC055732,
Species
mouse
UniGene ID
Mm.248266
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.