human KEAP1 shRNA silencing AAV

Name
AAV-h-KEAP1-shRNA

Cat No
shAAV-212864

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human KEAP1.

shAAV-212864

AAV-h-KEAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KEAP1 (kelch like ECH associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

INrf2; KLHL19

Description (Vector)

KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Gene ID

9817

Gene Name (Vector)

kelch like ECH associated protein 1

Gene Symbol

KEAP1

HGNC ID

HGNC:23177

ORF Size (aa)

1875

ORF Size (bp)

1875 bp

RefSeq ID

NM_012289

RefSeq Synonyms

NM_203500, NM_012289, BC015945, BC002930, BC002417,

Species

human

UniGene ID

Hs.465870

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.