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mouse KCNIP3 shRNA silencing AAV

Name 
AAV-m-KCNIP3-shRNA
Cat No 
shAAV-262645
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Kcnip3.

shAAV-262645
AAV-m-KCNIP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Kcnip3 (Kv channel interacting protein 3, calsenilin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
4933407H12Rik; AI413860; Csen; DREAM; KChIP3; R74849
Description (Vector)
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity)|Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface|Function: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
Gene ID
56461
Gene Name (Vector)
Kv channel interacting protein 3, calsenilin
Gene Symbol
Kcnip3
ORF Size (aa)
771
ORF Size (bp)
771 bp
RefSeq ID
NM_019789
RefSeq Synonyms
NM_019789, NM_001291005, NM_001111331, BC057329, BC047139, BC026980,
Species
mouse
UniGene ID
Mm.315292

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.