mouse KAT5 shRNA silencing AAV

Name
AAV-m-KAT5-shRNA

Cat No
shAAV-262572

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Kat5.

shAAV-262572

AAV-m-KAT5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Kat5 (K(lysine) acetyltransferase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AI839539; CPLA2; Htatip; Htatip1; PLIP; Tip55; Tip60

Description (Vector)

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

Gene ID

81601

Gene Name (Vector)

K(lysine) acetyltransferase 5

Gene Symbol

Kat5

ORF Size (aa)

1386

ORF Size (bp)

1386 bp

RefSeq ID

NM_178637

RefSeq Synonyms

NM_178637, NM_001199249, NM_001199248, NM_001199247, BC129968, BC110675,

Species

mouse

UniGene ID

Mm.228930

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.