mouse ITGA2B shRNA silencing AAV

Name
AAV-m-ITGA2B-shRNA

Cat No
shAAV-262427

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Itga2b.

shAAV-262427

AAV-m-ITGA2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Itga2b (integrin alpha 2b). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AI172977; alphaIIb; CD41; CD41B; GpIIb

Description (Vector)

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Gene ID

16399

Gene Name (Vector)

integrin alpha 2b

Gene Symbol

Itga2b

ORF Size (aa)

3102

ORF Size (bp)

3102 bp

RefSeq ID

NM_010575

RefSeq Synonyms

NM_010575, BC137570, BC120493,

Species

mouse

UniGene ID

Mm.26646

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.