mouse ITGA2B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Itga2b.
shADV-262427
Ad-m-ITGA2B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Itga2b (integrin alpha 2b). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI172977; alphaIIb; CD41; CD41B; GpIIb
Description (Vector)
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Gene ID
16399
Gene Name (Vector)
integrin alpha 2b
Gene Symbol
Itga2b
ORF Size (aa)
3102
ORF Size (bp)
3102 bp
RefSeq ID
NM_010575
RefSeq Synonyms
NM_010575, BC137570, BC120493,
Species
mouse
UniGene ID
Mm.26646
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.