mouse IKBKB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ikbkb.
shAAV-262072
AAV-m-IKBKB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ikbkb (inhibitor of kappaB kinase beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI132552; IKK-2; IKK-beta; IKK2; IKKbeta; IKK[b]
Description (Vector)
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Gene ID
16150
Gene Name (Vector)
inhibitor of kappaB kinase beta
Gene Symbol
Ikbkb
ORF Size (aa)
2274
ORF Size (bp)
2274 bp
RefSeq ID
NM_010546
RefSeq Synonyms
NM_010546, NM_001159774, BC037723,
Species
mouse
UniGene ID
Mm.277886
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.