mouse H2AFY2 shRNA silencing AAV

Name
AAV-m-H2AFY2-shRNA

Cat No
shAAV-261059

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse H2afy2.

shAAV-261059

AAV-m-H2AFY2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse H2afy2 (H2A histone family, member Y2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

macroH2A2

Description (Vector)

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Gene ID

404634

Gene Name (Vector)

H2A histone family, member Y2

Gene Symbol

H2afy2

ORF Size (aa)

1119

RefSeq ID

NM_207000

RefSeq Synonyms

NM_207000, BC127144, BC107280, BC107279, BC046794, BC045140,

Species

mouse

UniGene ID

Mm.272870

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.