mouse FBXW7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Fbxw7.
shAAV-259274
AAV-m-FBXW7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Fbxw7 (F-box and WD-40 domain protein 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; SEL-10
Description (Vector)
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Gene ID
50754
Gene Name (Vector)
F-box and WD-40 domain protein 7
Gene Symbol
Fbxw7
ORF Size (aa)
1044
RefSeq ID
NM_080428
RefSeq Synonyms
NM_080428, NM_001177774, NM_001177773, BC131648, BC085184,
Species
mouse
UniGene ID
Mm.196475
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.