mouse FAM175A shRNA silencing AAV

Name
AAV-m-FAM175A-shRNA

Cat No
shAAV-259024

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Fam175a.

shAAV-259024

AAV-m-FAM175A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Fam175a (family with sequence similarity 175, member A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

3830405G04Rik; 5630400M01Rik; AI506069; AL024423; AV118690; Ccdc98

Description (Vector)

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

Gene ID

70681

Gene Name (Vector)

family with sequence similarity 175, member A

Gene Symbol

Fam175a

ORF Size (aa)

897

ORF Size (bp)

897 bp

RefSeq ID

NM_172405

RefSeq Synonyms

NM_172405, BC029845,

Species

mouse

UniGene ID

Mm.221269

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.