mouse EYA2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Eya2.
shAAV-258817
AAV-m-EYA2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Eya2 (EYA transcriptional coactivator and phosphatase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Eab1
Description (Vector)
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
Gene ID
14049
Gene Name (Vector)
EYA transcriptional coactivator and phosphatase 2
Gene Symbol
Eya2
ORF Size (aa)
1599
ORF Size (bp)
1599 bp
RefSeq ID
NM_010165
RefSeq Synonyms
NM_010165, NM_001271963, NM_001271962, BC003755,
Species
mouse
UniGene ID
Mm.282719
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.