mouse EXOSC9 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Exosc9.
shAAV-258803
AAV-m-EXOSC9-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Exosc9 (exosome component 9). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
p5; p6; PM/Scl-75; Pmscl1; RRP45
Description (Vector)
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
Gene ID
50911
Gene Name (Vector)
exosome component 9
Gene Symbol
Exosc9
ORF Size (aa)
1317
ORF Size (bp)
1317 bp
RefSeq ID
NM_019393
RefSeq Synonyms
NM_019393, BC158075, BC052156, BC005622,
Species
mouse
UniGene ID
Mm.116711
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.