mouse ENPP2 shRNA silencing AAV

Name 
AAV-m-ENPP2-shRNA
Cat No 
shAAV-258386
Availability
Immediate
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Enpp2.

shAAV-258386
AAV-m-ENPP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha; Pdnp2
Description (Vector)
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Gene ID
18606
Gene Name (Vector)
ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene Symbol
Enpp2
ORF Size (aa)
2589
ORF Size (bp)
2589 bp
RefSeq ID
NM_015744
RefSeq Synonyms
NM_015744, NM_001285995, NM_001285994, NM_001136077, BC058759, BC003264,
Species
mouse
UniGene ID
Mm.250256

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.