mouse DYRK2 shRNA silencing AAV

Name
AAV-m-DYRK2-shRNA

Cat No
shAAV-257593

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Dyrk2.

shAAV-257593

AAV-m-DYRK2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

1810038L18Rik

Description (Vector)

Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development. Phosphorylates CRMP4/DPYSL3, EIF2B5, GYS1, p53/TP53, TAU/MAPT, STAT3 and KATNA1. Regulates p53/TP53 by phosphorylation on 'Ser-46' to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of its downstream substrate, KATNA1. Phosphorylation of CRMP4/DPYSL3 promotes its subsequent phosphorylation by GSK3.

Gene ID

69181

Gene Name (Vector)

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Gene Symbol

Dyrk2

ORF Size (aa)

1800

ORF Size (bp)

1800 bp

RefSeq ID

NM_001014390

RefSeq Synonyms

NM_001014390, BC085145,

Species

mouse

UniGene ID

Mm.458174

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.