mouse CLEC5A shRNA silencing AAV

Cat. No: shAAV-255647

Availability: 6-8 weeks

Name: AAV-m-CLEC5A-shRNA

This is an AAV expressing shRNA for silencing of Mouse Clec5a.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Clec5a
Gene Name: C-type lectin domain family 5, member a
Gene ID: 23845
Gene Synonyms: Clecsf5; Ly100; MDL-1; Mdl1
ORF Size: 573 bp
RefSeq#: NM_021364
Gene Description: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
UniGene ID: Mm.103765