NFkB inhibitor, beta Adenovirus

Name 
Ad-iKBb
Cat No 
1382
Availability
Immediate
Categories
Adenovirus, Over-Expression

Members of the IKB family can be divided into four groups including IkB-Alpha (including proteins previously referred to as pp40 and MAD-3), IKB-beta, IKB-gamma (a 70 kDa protein identical in sequence to the C-terminal domain of the p105 precursor of NFkB p50) and IkB-epsilon. Members of the IKB family exhibit differential inhibition of the DNA binding activity of various NFkB homodimeric and heterodimeric complexes. A functionally related protein, Bcl-3, is overexpressed in chronic lymphocytic leukemia.

1382
Ad-iKBb

Ready-to-use NFkB inhibitor, beta Adenovirus. Ad-iKBb, “NFkB inhibitor, beta “, IKBB,TRIP9,NFKBIB adenovirus 1382

$690.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ikappaBbeta; I-kappa-B-beta; IKBB; ikB-B; ikB-beta; NF-kappa-B inhibitor beta; NF-kappa-BIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP9; TRIP-9
Description (eCommerce)
Activity of the transcription factor NF-kappa B is regulated by inhibitor proteins that interact with NF-kappa B and inhibit their DNA binding activity. These inhibitor proteins are members of the I kappa B family of proteins and include I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa Bp105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. Association with I kappa B proteins sequesters NF-kappa B in the cytoplasm to regulate its activity. The Phosphorylation of I kappa B by the I kappa B kinase complex (IKK) results in the ubiquitination and degradation of I kappa B and the release and translocation of NF-kappa B to the nucleus.
Description (Vector)
NFKBIB belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
Gene ID
4793
Gene Name (eCommerce)
NFKB inhibitor beta
Gene Name (Vector)
NFKB inhibitor beta
Gene Symbol
NFKBIB
HGNC ID
HGNC:7798
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1071
ORF Size (bp)
1071 bp
Protein Name (eCommerce)
NF-kappa-B inhibitor beta
RefSeq ID
NM_002503
RefSeq Synonyms
NM_002503, NM_001243116, NM_001001716, BC015528,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,Host-Virus Interactions,Hypoxia,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,Neurobiology,NF-kB Signaling,Prolactin Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TWEAK Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Activity of the transcription factor NF-kappa B is regulated by inhibitor proteins that interact with NF-kappa B and inhibit their DNA binding activity. These inhibitor proteins are members of the I kappa B family of proteins and include I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa Bp105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. Association with I kappa B proteins sequesters NF-kappa B in the cytoplasm to regulate its activity. The Phosphorylation of I kappa B by the I kappa B kinase complex (IKK) results in the ubiquitination and degradation of I kappa B and the release and translocation of NF-kappa B to the nucleus.
UniGene ID
Hs.9731
UniProt ID (eCommerce)
Q15653

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.