mouse CLEC4E shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Clec4e.
shAAV-255643
AAV-m-CLEC4E-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Clec4e (C-type lectin domain family 4, member e). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C86253; Clecsf9; Mincle
Description (Vector)
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
Gene ID
56619
Gene Name (Vector)
C-type lectin domain family 4, member e
Gene Symbol
Clec4e
ORF Size (aa)
645
ORF Size (bp)
645 bp
RefSeq ID
NM_019948
RefSeq Synonyms
NM_019948, BC003218,
Species
mouse
UniGene ID
Mm.248327
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.