mouse CCNC shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ccnc.
shAAV-254858
AAV-m-CCNC-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ccnc (cyclin C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI451004; AU020987; CG1C
Description (Vector)
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Gene ID
51813
Gene Name (Vector)
cyclin C
Gene Symbol
Ccnc
ORF Size (aa)
579
ORF Size (bp)
579 bp
RefSeq ID
NM_016746
RefSeq Synonyms
NM_016746, NM_001290422, NM_001290420, NM_001122982, BC120677, BC120649, BC029211, BC003344,
Species
mouse
UniGene ID
Mm.278584
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.