mouse CBR1 shRNA silencing AAV

Name
AAV-m-CBR1-shRNA

Cat No
shAAV-254616

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Cbr1.

shAAV-254616

AAV-m-CBR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cbr1 (carbonyl reductase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AW261796; Cbr; CR

Description (Vector)

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Gene ID

12408

Gene Name (Vector)

carbonyl reductase 1

Gene Symbol

Cbr1

ORF Size (aa)

834

RefSeq ID

NM_007620

RefSeq Synonyms

NM_007620, BC158029, BC158026, BC012714,

Species

mouse

UniGene ID

Mm.26940

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.