mouse BCL2L1 shRNA silencing AAV

Name
AAV-m-BCL2L1-shRNA

Cat No
shAAV-253886

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Bcl2l1.

shAAV-253886

AAV-m-BCL2L1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Bcl2l1 (BCL2-like 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l; BclX

Description (Vector)

Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis|Function: Isoform Bcl-X(S) promotes apoptosis.

Gene ID

12048

Gene Name (Vector)

BCL2-like 1

Gene Symbol

Bcl2l1

ORF Size (aa)

702

RefSeq ID

NM_009743

RefSeq Synonyms

NM_009743, NM_001289739, NM_001289717, NM_001289716, BC089017, BC089016,

Species

mouse

UniGene ID

Mm.238213

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.