human BCL2L1 shRNA silencing AAV

apoptosis regulator Bcl-X; BCL2L; Bcl2-L-1; bcl-2-like protein 1; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52

Bcl-xL is part of the BCL-2 family of proteins that regulates apoptosis and cell cycle control. Bcl-xL is the protein product of the larger alternatively spliced isoform of Bcl-x. Bcl-xL functions similarly to BCL2 in promoting cell survival and inhibiting proliferation by promoting G0 arrest. Bcl-xL is located in the outer mitochondrial membrane and promotes cell survival by preventing mitochondrial release of cytochrome c and caspase activation in response to apoptotic signals.

BCL2L1 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

598

BCL2 like 1

BCL2 like 1

BCL2L1

HGNC:992

9606.0

702

702 bp

Bcl-2-like protein 1

NM_001191

NM_138578, NM_001322242, NM_001322240, NM_001322239, NM_001317921, NM_001317920, NM_001317919, NM_001191, BC019307,

Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Autophagy,Cancer,CD40 Signaling,Cell Cycle,Cytoskeleton,DNA Damage/Repair,EPO Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,NFAT Signaling,NF-kB Signaling,Parkinson's Disease,PI3K/Akt Signaling,Signal Transduction,Spermatogenesis,Synapse,TNF Signaling,Transcriptional Misregulation in Cancer

cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

human

Bcl-xL is part of the BCL-2 family of proteins that regulates apoptosis and cell cycle control. Bcl-xL is the protein product of the larger alternatively spliced isoform of Bcl-x. Bcl-xL functions similarly to BCL2 in promoting cell survival and inhibiting proliferation by promoting G0 arrest. Bcl-xL is located in the outer mitochondrial membrane and promotes cell survival by preventing mitochondrial release of cytochrome c and caspase activation in response to apoptotic signals.

Hs.516966

Q07817