mouse ANGPT2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Angpt2.
shAAV-252611
AAV-m-ANGPT2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Angpt2 (angiopoietin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Agpt2; Ang-2; Ang2
Description (Vector)
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Gene ID
11601
Gene Name (Vector)
angiopoietin 2
Gene Symbol
Angpt2
ORF Size (aa)
1491
ORF Size (bp)
1491 bp
RefSeq ID
NM_007426
RefSeq Synonyms
NM_007426, BC138313, BC138309, BC027216,
Species
mouse
UniGene ID
Mm.439874
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.