mouse ACD shRNA silencing AAV

Name
AAV-m-ACD-shRNA

Cat No
shAAV-251902

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Acd.

shAAV-251902

AAV-m-ACD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Acd (adrenocortical dysplasia). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.

Gene ID

497652

Gene Name (Vector)

adrenocortical dysplasia

Gene Symbol

Acd

ORF Size (aa)

1251

ORF Size (bp)

1251 bp

RefSeq ID

NM_001012638

RefSeq Synonyms

NM_001012638, BC138695, BC138694,

Species

mouse

UniGene ID

Mm.12964

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.