mouse NR2C2 shRNA silencing AAV

Name
AAV-m-NR2C2-shRNA

Cat No
shAAV-251552

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Nr2c2.

shAAV-251552

AAV-m-NR2C2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nr2c2 (nuclear receptor subfamily 2, group C, member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

mKIAA4145; TAK1; Tr4

Description (Vector)

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Gene ID

22026

Gene Name (Vector)

nuclear receptor subfamily 2, group C, member 2

Gene Symbol

Nr2c2

ORF Size (aa)

1791

ORF Size (bp)

1791 bp

RefSeq ID

NM_011630

RefSeq Synonyms

NM_011630, NM_001347342, BC103686, BC103684, BC103683,

Species

mouse

UniGene ID

Mm.87062

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.