mouse RIPK1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ripk1.
shAAV-251116
AAV-m-RIPK1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D330015H01Rik; Rinp; RIP; Rip1
Description (Vector)
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
Gene ID
19766
Gene Name (Vector)
receptor (TNFRSF)-interacting serine-threonine kinase 1
Gene Symbol
Ripk1
ORF Size (aa)
1971
ORF Size (bp)
1971 bp
RefSeq ID
NM_009068
RefSeq Synonyms
NM_009068, BC058162, BC054542, BC050905,
Species
mouse
UniGene ID
Mm.374799
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.