mouse TTI1 shRNA silencing AAV

Name
AAV-m-TTI1-shRNA

Cat No
shAAV-250796

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Tti1.

shAAV-250796

AAV-m-TTI1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Tti1 (TELO2 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2610036D13Rik; AI449463

Description (Vector)

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

Gene ID

75425

Gene Name (Vector)

TELO2 interacting protein 1

Gene Symbol

Tti1

ORF Size (aa)

3258

ORF Size (bp)

3258 bp

RefSeq ID

NM_029282

RefSeq Synonyms

NM_029282, BC053067,

Species

mouse

UniGene ID

Mm.29068

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.