human RC3H2 shRNA silencing AAV

Name 
AAV-h-RC3H2-shRNA
Cat No 
shAAV-234397
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RC3H2.

shAAV-234397
AAV-h-RC3H2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RC3H2 (ring finger and CCCH-type domains 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
membrane associated DNA binding protein; membrane-associated nucleic acid-binding protein; MNAB; ring finger and CCCH-type zinc finger domain-containing protein 2; ring finger and CCCH-type zinc finger domains 2; RING finger protein 164; RING-type E3 ubiquitin transferase Roquin-2; RNF164; roquin-2
Description (eCommerce)
Roquin-2 is encoded by the gene RC3H2, also known as MNAB. Roquin-2 is a post-transcriptional repressor of mRNAs containing a conserved stem loop motif called the constitutive decay element (CDE). Binding to the CDE promotes mRNA deadenylation and degradation [taken from UniProtKB (Entry: Q9HBD1)].
Gene ID
54542
Gene Name (eCommerce)
ring finger and CCCH-type domains 2
Gene Name (Vector)
ring finger and CCCH-type domains 2
Gene Symbol
RC3H2
HGNC ID
HGNC:21461
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1521
ORF Size (bp)
1521 bp
Protein Name (eCommerce)
Roquin-2
RefSeq ID
NM_018835
RefSeq Synonyms
NM_018835, NM_001100588, BC044642,
Research Areas
RNA Binding,Zinc-finger
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Roquin-2 is encoded by the gene RC3H2, also known as MNAB. Roquin-2 is a post-transcriptional repressor of mRNAs containing a conserved stem loop motif called the constitutive decay element (CDE). Binding to the CDE promotes mRNA deadenylation and degradation [taken from UniProtKB (Entry: Q9HBD1)].
UniProt ID (eCommerce)
Q9HBD1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.