human SLC30A8 shRNA silencing AAV

Name
AAV-h-SLC30A8-shRNA

Cat No
shAAV-234269

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SLC30A8.

shAAV-234269

AAV-h-SLC30A8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC30A8 (solute carrier family 30 member 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ZnT-8; ZNT8

Description (Vector)

SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

169026

Gene Name (Vector)

solute carrier family 30 member 8

Gene Symbol

SLC30A8

HGNC ID

HGNC:20303

ORF Size (aa)

963

RefSeq ID

NM_173851

RefSeq Synonyms

NM_173851, NM_001172815, NM_001172814, NM_001172813, NM_001172811, BC126446,

Species

human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.