human SYNE2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SYNE2.
shAAV-234260
AAV-h-SYNE2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SYNE2 (spectrin repeat containing nuclear envelope protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EDMD5; KASH domain-containing protein 2; KASH2; Nesp2; nesprin 2; Nesprin-2; NUA; NUANCE; nuclear envelope spectrin repeat protein 2; nucleus and actin connecting element protein; polytrophin; Protein NUANCE; spectrin repeat containing, nuclear envelope 2; synaptic nuclear envelope protein 2; synaptic nuclei expressed gene 2; SYNE-2; TROPH
Description (eCommerce)
SYNE2/Nesprin 2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus [taken from NCBI Entrez Gene (Gene ID: 23224)].
Description (Vector)
SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
23224
Gene Name (eCommerce)
spectrin repeat containing nuclear envelope protein 2
Gene Name (Vector)
spectrin repeat containing nuclear envelope protein 2
Gene Symbol
SYNE2
HGNC ID
HGNC:17084
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
858
Protein Name (eCommerce)
Nesprin-2
RefSeq ID
NM_015180
RefSeq Synonyms
NM_182914, NM_182913, NM_182910, NM_015180, BC042134,
Research Areas
Cytoskeleton,Immunology,Mitochondrion
Research Areas (Faceted)
cell_biology,immunology
Species
human
Target Sentence
SYNE2/Nesprin 2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus [taken from NCBI Entrez Gene (Gene ID: 23224)].
UniProt ID (eCommerce)
Q8WXH0
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.