human MAPT shRNA silencing AAV

Name
AAV-h-MAPT-shRNA

Cat No
shAAV-233559

Availability
Immediate

This is an AAV expressing shRNA for silencing of Human MAPT.

shAAV-233559

AAV-h-MAPT-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAPT (microtubule associated protein tau). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU

Description (Vector)

MAPT encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Gene ID

4137

Gene Name (Vector)

microtubule associated protein tau

Gene Symbol

MAPT

HGNC ID

HGNC:6893

ORF Size (aa)

1152

ORF Size (bp)

1152 bp

RefSeq ID

NM_005910

RefSeq Synonyms

NM_016841, NM_016835, NM_016834, NM_005910, NM_001203252, NM_001203251, NM_001123067, NM_001123066, BC114948,

Species

human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.