human SYNM shRNA silencing AAV

Name 
AAV-h-SYNM-shRNA
Cat No 
shAAV-232489
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SYNM.

shAAV-232489
AAV-h-SYNM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SYNM (synemin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
desmuslin; DMN; SYN; synemin; synemin alpha; synemin beta; synemin, intermediate filament protein
Description (eCommerce)
Synemin is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle [taken from NCBI Entrez Gene (Gene ID: 23336)].
Description (Vector)
SYNM is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene.
Gene ID
23336
Gene Name (eCommerce)
synemin
Gene Name (Vector)
synemin
Gene Symbol
SYNM
HGNC ID
HGNC:24466
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4698
ORF Size (bp)
4698 bp
Protein Name (eCommerce)
Synemin
RefSeq ID
NM_015286
RefSeq Synonyms
NM_145728, NM_015286, BC151243,
Research Areas
Cytoskeleton,Neurobiology
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
Synemin is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle [taken from NCBI Entrez Gene (Gene ID: 23336)].
UniGene ID
Hs.
UniProt ID (eCommerce)
O15061

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.