mouse TRIM11 Adenovirus
This is an Adenovirus expressing Mouse Trim11.
ADV-274963
Ad-m-TRIM11
Ready-to-use Adenovirus expressing Mouse Trim11 (tripartite motif-containing 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Gene ID
94091
Gene Name (Vector)
tripartite motif-containing 11
Gene Symbol
Trim11
ORF Size (aa)
1452
ORF Size (bp)
1452 bp
RefSeq ID
NM_053168
RefSeq Synonyms
NM_053168, NM_001290988, BC020102,
Species
mouse
UniGene ID
Mm.248049
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.