human IRS4 shRNA silencing AAV

Name 
AAV-h-IRS4-shRNA
Cat No 
shAAV-231385
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human IRS4.

shAAV-231385
AAV-h-IRS4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IRS4 (insulin receptor substrate 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
160 kDa phosphotyrosine protein; insulin receptor substrate 4; IRS-4; phosphoprotein of 160 kDa; pp160; PY160
Description (eCommerce)
Insulin receptor substrate 4 (IRS4) is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation [taken from NCBI Entrez Gene (Gene ID: 8471)].
Description (Vector)
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation..
Gene ID
8471
Gene Name (eCommerce)
insulin receptor substrate 4
Gene Name (Vector)
insulin receptor substrate 4
Gene Symbol
IRS4
HGNC ID
HGNC:6128
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3771
ORF Size (bp)
3771 bp
Protein Name (eCommerce)
Insulin receptor substrate 4
RefSeq ID
NM_003604
RefSeq Synonyms
NM_003604, BC156977, BC156188,
Research Areas
IGF-1 Signaling,Insulin Signaling,Leptin Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
Insulin receptor substrate 4 (IRS4) is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation [taken from NCBI Entrez Gene (Gene ID: 8471)].
UniGene ID
Hs.460872
UniProt ID (eCommerce)
O14654

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.