human SPANXA1 shRNA silencing AAV

Name
AAV-h-SPANXA1-shRNA

Cat No
shAAV-230259

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SPANXA1.

shAAV-230259

AAV-h-SPANXA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPANXA1 (sperm protein associated with the nucleus, X-linked, family member A1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CT11.1; NAP-X; SPAN-X; SPAN-Xa; SPAN-Xb; SPANX; SPANX-A

Description (Vector)

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis.

Gene ID

30014

Gene Name (Vector)

sperm protein associated with the nucleus, X-linked, family member A1

Gene Symbol

SPANXA1

HGNC ID

HGNC:11218

ORF Size (aa)

291

RefSeq ID

NM_013453

RefSeq Synonyms

NM_013453, BC148759, BC141462, BC069816, BC069393,

Species

human

UniGene ID

Hs.334464

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.