human NEXN shRNA silencing AAV

Name
AAV-h-NEXN-shRNA

Cat No
shAAV-230087

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NEXN.

shAAV-230087

AAV-h-NEXN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NEXN (nexilin F-actin binding protein). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CMH20; F-actin-binding protein; NELIN; nexilin

Description (eCommerce)

Nexilin is a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC [taken from NCBI Entrez Gene (Gene ID: 91624)].

Description (Vector)

NEXN encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.

Gene ID

91624

Gene Name (eCommerce)

nexilin F-actin binding protein

Gene Name (Vector)

nexilin F-actin binding protein

Gene Symbol

NEXN

HGNC ID

HGNC:29557

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1665

ORF Size (bp)

1665 bp

Protein Name (eCommerce)

Nexilin

RefSeq ID

NM_144573

RefSeq Synonyms

NM_144573, NM_001172309, BC114445, BC114444, BC111395,

Research Areas

Cardiology,Cardiomyopathy,Cardiovascular,Cytoskeleton,Immunology

Research Areas (Faceted)

cardiovascular,cell_biology,immunology

Species

human

Target Sentence

Nexilin is a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC [taken from NCBI Entrez Gene (Gene ID: 91624)].

UniGene ID

Hs.612385

UniProt ID (eCommerce)

Q0ZGT2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.