human MAPK14 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAPK14.
shAAV-229469
AAV-h-MAPK14-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAPK14 (mitogen-activated protein kinase 14). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CSAID-binding protein; Csaids binding protein; CSBP; CSBP1; CSBP2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase Mxi2; MAP kinase p38 alpha; MAPK 14; MAX-interacting protein 2; mitogen-activated protein kinase 14; mitogen-activated protein kinase p38 alpha; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK2A; stress-activated protein kinase 2A
Description (eCommerce)
p38 MAPK is a member of the MAP (mitogen-activated protein) kinase family that is involved in cellular signaling for a wide variety of activities which includes proliferation, differentiation, and transcriptional regulation. p38 MAPK is responsive to growth factors as well as a variety of cellular stress signals such as UV light, inflammatory cytokines, and osmotic shock. Substrates of P38 MAPK include ATF2, MEF2C, MAX, CDC25B and p53. p38 MAPK is activated by MAP kinase kinases such as MAP2K3, MAP2K6, and MAP2K4.
Gene ID
1432
Gene Name (eCommerce)
mitogen-activated protein kinase 14
Gene Name (Vector)
mitogen-activated protein kinase 14
Gene Symbol
MAPK14
HGNC ID
HGNC:6876
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1083
ORF Size (bp)
1083 bp
Protein Name (eCommerce)
Mitogen-activated protein kinase 14
RefSeq ID
NM_139012
RefSeq Synonyms
NM_139014, NM_139013, NM_139012, NM_001315, BC031574, BC000092,
Research Areas
Aging,Alzheimer's Disease,Amyotrophic Lateral Sclerosis (ALS),Angiogenesis,Apoptosis,Autophagy,B-cell Receptor Signaling,BDNF Signaling,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cell Cycle,DNA Damage/Repair,EGFR Signaling,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,GnRH Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,mRNA Binding,Neurobiology,Neurodegeneration,NFAT Signaling,NF-kB Signaling,NGF Signaling,p53 Signaling,Parkinson's Disease,Prolactin Signaling,Prostate Cancer,RAC1 Signaling,RANKL-RANK Signaling,RNA Processing,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TSH Signaling,TSLP Signaling,TWEAK Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
p38 MAPK is a member of the MAP (mitogen-activated protein) kinase family that is involved in cellular signaling for a wide variety of activities which includes proliferation, differentiation, and transcriptional regulation. p38 MAPK is responsive to growth factors as well as a variety of cellular stress signals such as UV light, inflammatory cytokines, and osmotic shock. Substrates of P38 MAPK include ATF2, MEF2C, MAX, CDC25B and p53. p38 MAPK is activated by MAP kinase kinases such as MAP2K3, MAP2K6, and MAP2K4.
UniGene ID
Hs.485233
UniProt ID (eCommerce)
Q16539
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.