human ZNF384 shRNA silencing AAV

Name 
AAV-h-ZNF384-shRNA
Cat No 
shAAV-228524
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ZNF384.

shAAV-228524
AAV-h-ZNF384-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ZNF384 (zinc finger protein 384). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAG repeat protein 1; CAGH1; CAGH1A; Cas-interacting zinc finger protein; CI; ZERDA2; expanded repeat domain, CAG/CTG 2; NMP4; NP; Nuclear matrix protein 4; nuclear matrix transcription factor 4; TNRC1; trinucleotide repeat-containing gene 1 protein; zinc finger protein 384
Description (eCommerce)
CAS-interacting zinc finger protein (CIZ) is also known as nuclear matrix protein 4 (NMP4) and the gene name zinc finger protein 384 (ZNF384). CIZ is a C2H2-type zinc finger protein, which may function as a transcription factor. CIZ appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling [taken from NCBI Entrez Gene (Gene ID: 171017)].
Description (Vector)
ZNF384 encodes a C2H2-type zinc finger protein, which may function as a transcription factor. ZNF384 also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7.
Gene ID
171017
Gene Name (eCommerce)
zinc finger protein 384
Gene Name (Vector)
zinc finger protein 384
Gene Symbol
ZNF384
HGNC ID
HGNC:11955
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1383
ORF Size (bp)
1383 bp
Protein Name (eCommerce)
Zinc finger protein 384
RefSeq ID
NM_133476
RefSeq Synonyms
NM_133476, NM_001135734, NM_001039920, BC053361,
Research Areas
Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
CAS-interacting zinc finger protein (CIZ) is also known as nuclear matrix protein 4 (NMP4) and the gene name zinc finger protein 384 (ZNF384). CIZ is a C2H2-type zinc finger protein, which may function as a transcription factor. CIZ appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling [taken from NCBI Entrez Gene (Gene ID: 171017)].
UniGene ID
Hs.714839
UniProt ID (eCommerce)
Q8TF68

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.