human ZHX3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ZHX3.
shAAV-228250
AAV-h-ZHX3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ZHX3 (zinc fingers and homeoboxes 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TIX1; triple homeobox 1; triple homeobox protein 1; zinc finger and homeodomain protein 3; zinc fingers and homeoboxes protein 3
Description (eCommerce)
ZHX3 (zinc-fingers and homeoboxes 3) was identified as a factor that heterodimerizes with the transcriptional repressor, ZHX1. ZHX3 has also been found to partner with ZHX2 and itself, as a dimer, to play a role in transcriptional repression. Recently, studies in a rat model for proteinuria have revealed an important role for ZHX3 in glomerular disease development and the regulation of gene expression in glomerular podocytes.
Description (Vector)
ZHX3 encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.
Gene ID
23051
Gene Name (eCommerce)
zinc fingers and homeoboxes 3
Gene Name (Vector)
zinc fingers and homeoboxes 3
Gene Symbol
ZHX3
HGNC ID
HGNC:15935
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2910
ORF Size (bp)
2910 bp
Protein Name (eCommerce)
Zinc fingers and homeoboxes protein 3
RefSeq ID
NM_015035
RefSeq Synonyms
NM_015035, BC068569,
Research Areas
Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
ZHX3 (zinc-fingers and homeoboxes 3) was identified as a factor that heterodimerizes with the transcriptional repressor, ZHX1. ZHX3 has also been found to partner with ZHX2 and itself, as a dimer, to play a role in transcriptional repression. Recently, studies in a rat model for proteinuria have revealed an important role for ZHX3 in glomerular disease development and the regulation of gene expression in glomerular podocytes.
UniGene ID
Hs.380133
UniProt ID (eCommerce)
Q9H4I2
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.