human ZCCHC11 shRNA silencing AAV

Name
AAV-h-ZCCHC11-shRNA

Cat No
shAAV-228113

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ZCCHC11.

shAAV-228113

AAV-h-ZCCHC11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ZCCHC11 (zinc finger CCHC-type containing 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PAP associated domain containing 3; PAPD3; TENT3A; terminal uridylyltransferase 4; TUTase 4; ZCCHC11; zinc finger CCHC domain-containing protein 11; zinc finger CCHC-type containing 11; zinc finger, CCHC domain containing 11

Description (eCommerce)

ZCCHC11 (zinc-finger CCHC domain-containing protein 11) functions as a uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs.

Description (Vector)

ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 (PubMed 19701194)).(supplied by OMIM, Jan 2011)

Gene ID

23318

Gene Name (eCommerce)

terminal uridylyl transferase 4

Gene Name (Vector)

zinc finger CCHC-type containing 11

Gene Symbol

ZCCHC11

HGNC ID

HGNC:28981

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

4938

ORF Size (bp)

4938 bp

Protein Name (eCommerce)

Terminal uridylyltransferase 4

RefSeq ID

NM_015269

RefSeq Synonyms

NM_015269, NM_001009881, BC131734,

Research Areas

Cell Biology,Metabolism/Metabolic Process,RNA Processing,Transcription Factor/Regulator,Translational Control,Zinc-finger

Research Areas (Faceted)

cell_biology,metabolism,genetics,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.655407

UniProt ID (eCommerce)

Q5TAX3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.