human XDH shRNA silencing AAV

Name
AAV-h-XDH-shRNA

Cat No
shAAV-227879

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human XDH.

shAAV-227879

AAV-h-XDH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human XDH (xanthine dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

XAN1; XO; XOR

Description (Vector)

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

Gene ID

7498

Gene Name (Vector)

xanthine dehydrogenase

Gene Symbol

XDH

HGNC ID

HGNC:12805

ORF Size (aa)

4002

ORF Size (bp)

4002 bp

RefSeq ID

NM_000379

RefSeq Synonyms

NM_000379, BC166696,

Species

human

UniGene ID

Hs.250

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.