human XCR1 shRNA silencing AAV

Name
AAV-h-XCR1-shRNA

Cat No
shAAV-227876

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human XCR1.

shAAV-227876

AAV-h-XCR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human XCR1 (X-C motif chemokine receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CCXCR1; GPR5

Description (Vector)

XCR1 is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene ID

2829

Gene Name (Vector)

X-C motif chemokine receptor 1

Gene Symbol

XCR1

HGNC ID

HGNC:1625

ORF Size (aa)

1002

RefSeq ID

NM_005283

RefSeq Synonyms

NM_005283, NM_001024644, BC095533, BC069589, BC069075,

Species

human

UniGene ID

Hs.248116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.