human WNK4 shRNA silencing AAV

Name 
AAV-h-WNK4-shRNA
Cat No 
shAAV-227809
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human WNK4.

shAAV-227809
AAV-h-WNK4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human WNK4 (WNK lysine deficient protein kinase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PHA2B; PRKWNK4
Description (Vector)
WNK4 encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
Gene ID
65266
Gene Name (Vector)
WNK lysine deficient protein kinase 4
Gene Symbol
WNK4
HGNC ID
HGNC:14544
ORF Size (aa)
3732
ORF Size (bp)
3732 bp
RefSeq ID
NM_032387
RefSeq Synonyms
NM_032387, NM_001321299, BC136664,
Species
human
UniGene ID
Hs.105448

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.