human WDR42A shRNA silencing AAV

Name
AAV-h-WDR42A-shRNA

Cat No
shAAV-227678

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DCAF8.

shAAV-227678

AAV-h-WDR42A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DCAF8 (DDB1 and CUL4 associated factor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

81

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DDB1- and CUL4-associated factor 8; GAN2; H326; WD repeat domain 42A; WD repeat-containing protein 42A; WDR42A

Description (eCommerce)

WDR42A (WD repeat-containing protein 42A) contains seven WD repeats and is a member of the WD family of proteins. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. WD proteins are involved in a variety of cellular processes. The function of WDR42A has not been characterized.

Description (Vector)

DCAF8 encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene.

Gene ID

50717

Gene Name (eCommerce)

DDB1 and CUL4 associated factor 8

Gene Name (Vector)

DDB1 and CUL4 associated factor 8

Gene Symbol

DCAF8

HGNC ID

HGNC:24891

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1794

ORF Size (bp)

1794 bp

Protein Name (eCommerce)

DDB1- and CUL4-associated factor 8

RefSeq ID

NM_015726

RefSeq Synonyms

NM_015726, BC099846, BC099709, BC098271,

Research Areas

Cell Biology,Translational Control,Ubiquitination

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

WDR42A (WD repeat-containing protein 42A) contains seven WD repeats and is a member of the WD family of proteins. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. WD proteins are involved in a variety of cellular processes. The function of WDR42A has not been characterized.

UniGene ID

Hs.632447

UniProt ID (eCommerce)

Q5TAQ9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.