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human WASF1 shRNA silencing AAV

Name 
AAV-h-WASF1-shRNA
Cat No 
shAAV-227597
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human WASF1.

shAAV-227597
AAV-h-WASF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human WASF1 (WAS protein family member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SCAR1; WAVE; WAVE1
Description (Vector)
WASF1, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Gene ID
8936
Gene Name (Vector)
WAS protein family member 1
Gene Symbol
WASF1
HGNC ID
HGNC:12732
ORF Size (aa)
1680
ORF Size (bp)
1680 bp
RefSeq ID
NM_003931
RefSeq Synonyms
NM_003931, NM_001024936, NM_001024935, NM_001024934, BC044591,
Species
human
UniGene ID
Hs.75850

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.