human VRK3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human VRK3.
shAAV-227558
AAV-h-VRK3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human VRK3 (vaccinia related kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
VRK3 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. VRK3 is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms.
Gene ID
51231
Gene Name (Vector)
vaccinia related kinase 3
Gene Symbol
VRK3
HGNC ID
HGNC:18996
ORF Size (aa)
1239
RefSeq ID
NM_016440
RefSeq Synonyms
NM_016440, NM_001308420, NM_001025778, BC095449, BC023556,
Species
human
UniGene ID
Hs.443330
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.