human VPS72 shRNA silencing AAV

Name 
AAV-h-VPS72-shRNA
Cat No 
shAAV-227551
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human VPS72.

shAAV-227551
AAV-h-VPS72-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human VPS72 (vacuolar protein sorting 72 homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CFL1; Protein YL-1; Swc2; TCFL1; transcription factor-like 1; transformation suppressor gene YL-1; vacuolar protein sorting-associated protein 72 homolog; YL1; YL-1
Description (eCommerce)
YL1 is also known as vacuolar protein sorting-associated protein 72 homolog (VPS72). YL1 is a component of the NuA4 histone acetyltransferase complex and a probable DNA-binding transcriptional regulator involved in chromatin modification and remodeling.
Description (Vector)
VPS72 is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Gene ID
6944
Gene Name (eCommerce)
vacuolar protein sorting 72 homolog
Gene Name (Vector)
vacuolar protein sorting 72 homolog
Gene Symbol
VPS72
HGNC ID
HGNC:11644
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1095
Protein Name (eCommerce)
Vacuolar protein sorting-associated protein 72 homolog
RefSeq ID
NM_005997
RefSeq Synonyms
NM_005997, NM_001271088, NM_001271087, BC003151,
Research Areas
Chromatin Remodeling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
YL1 is also known as vacuolar protein sorting-associated protein 72 homolog (VPS72). YL1 is a component of the NuA4 histone acetyltransferase complex and a probable DNA-binding transcriptional regulator involved in chromatin modification and remodeling.
UniGene ID
Hs.2430
UniProt ID (eCommerce)
Q15906

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.